The research library
Evidence for the months ahead.
Read the studies behind longer-term GLP-1 care: what changed, who was studied, and what to bring to your next conversation.
Featured reading · Treatment continuity
What happens after the prescription ends?
The STEP 1 extension follows the year after semaglutide and structured lifestyle support stopped. Read the result with its limits in view.
Read the withdrawal studyStarting treatment
Maintaining progress
Planning what comes next
Evidence is a starting point for a clinical conversation.Read by the question on your mind.
Weight regain after stopping semaglutide: the STEP 1 extension
What the STEP 1 extension tells us about weight regain—and the questions it cannot answer about your next prescription.
STEP 1 extension · Study explainedMaintaining progressTirzepatide maintenance: what SURMOUNT-4 found
How SURMOUNT-4 separated continued tirzepatide from withdrawal, and why the denominator matters when reading weight regain.
SURMOUNT-4 · Study explainedBeyond the scaleGLP-1 muscle loss: what body-composition studies measure
How to read body-composition evidence without confusing lean tissue, skeletal muscle and everyday strength.
SURMOUNT-1 DXA substudy · Study explainedLonger-term healthSemaglutide and heart health: understanding SELECT
What SELECT showed in people with established cardiovascular disease—and how to read absolute benefit beside relative benefit.
SELECT · Study explainedFatigueDoes tirzepatide cause fatigue? What the label tells us.
Tiredness is a reported side effect. The useful next step is to describe the pattern, consider other explanations and know when to seek care.
Zepbound prescribing information · Study explainedConstipationSemaglutide and constipation: what to ask your care team.
How common constipation appears in Wegovy trials, what general guidance can help frame a conversation, and which symptoms need prompt assessment.
Wegovy label & NIDDK guidance · Study explainedHair sheddingGLP-1 hair loss: make sense of shedding and your next steps
Hair shedding during weight treatment deserves a closer look. Separate reported side effects, temporary shedding and the questions a clinician can answer.
Hair shedding & treatment follow-up · Study explainedNauseaGLP-1 nausea: everyday comfort and when to ask for help
What nausea reports mean, how to describe a difficult day, and why persistent symptoms need more than a list of food tips.
Digestive symptoms & care access · Study explainedWeight plateausSemaglutide weight-loss plateau: what a steady scale can mean
A plateau is a reason to review the bigger picture. Read the two-year STEP 5 findings, separate maintenance from early nonresponse, and prepare a useful follow-up.
STEP 5 & the longer view · Study explainedPut the reading into a practical plan.
Research explains treatment evidence. Our service guides help you clarify who follows up, what you pay and how care transfers when things change.